Disease-associated mutations prevent GPR56-collagen III interaction.
GPR56 is a member of the adhesion G protein-coupled receptor (GPCR) family.Mutations in GPR56 cause a devastating human brain malformation called bilateral frontoparietal polymicrogyria (BFPP).Using the N-terminal fragment of GPR56 (GPR56(N)) as a probe, we have recently demonstrated that collagen III is the ligand of GPR56 in the developing brain.